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This results in improved tumor control without added toxicity to healthy tissues

In contrast, BDO was partially consumed (~ 20 mM) (Fig

"Why the NIH Trial to Assess Chelation Therapy (TACT) should be abandoned"

This leads to the initiation of mitochondrial oxidative stress, which is amplified by the activation of c-Jun N-terminal kinase (JNK), resulting in mitochondrial dysfunction and opening of mitochondrial permeability transition pores