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In vivo, Clc demonstrated resilience to the harsh murine GIT environment in C57BL/6J mice, achieving 72% gliadin degradation in the stomach in an acute assay at a low enzyme:gliadin ratio (1:350), a key limitation in alternative glutenase development (Dunaevsky et al, 2021)

Since vitamin D is a potent stimulator of LL-37 production, this may partially explain the links seen between vitamin D deficiency and increased risk of infections, especially respiratory infections

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