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Analyses of TIF from tumours with WT Gclc and with Gclc knocked out (KO) showed that intracellular GSH synthesis partially contributed to tGSH levels in the TIF but not serum (Extended Data Fig

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Interaction with Medications Glutathione can interact with certain medications, affecting their efficacy

Garner et al., 2018), stimulate the retraction of these processes, allowing the cells to become amoeboid in their movement (Lehrmann et al., 1997), which is driven by several signaling molecules, including extracellular adenosine triphosphate (ATP), dead cells, and cellular debris (Davalos et al., 2005