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142 Taurine Taurine is a non-essential amino acid that is mainly obtained in the diet but can also be made in the liver and kidney from the amino acids cysteine and methionine

The PFD (also known as N-GSDMD) is located at the N-terminus and consists of 242 amino acids

DOI: 10.1093/jn/nxab309

Activation of the JAK/STAT3 pathway is a universal feature of astrocyte reactivity in models of different neurodegenerative disorders (Ben Haim et al., in vivo , inhibited this pathway and prevented astrocyte reactivity but also increased the number of mHTT and did not influence neuronal death (Ben Haim et al., 2014)

These molecules often correspond to secondary metabolites that contribute to the intrinsic therapeutic properties of PDEVs (Zhang et al., 2016)