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Primary Care Guidelines for B12 and Folate Testing Indications for B12 and Folate Testing No need to check B12 levels in patient on parenteral B12 treatment (they will always be high) There is no indication to check GPA or INF purely because of family history of autoimmune disease or hypothyroidism Care should be taken when prescribing folic acid alone If folic acid is given to a patient who is actually b12 deficient, this may precipitate irreversible neurological complications References 1

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The cofactors FAD and FMN, which include vitamin B2, are transferred to an electron by the enzyme methionine synthase reductase (MTRR) during the subsequent reactivation cycle