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Rangan, P, Siekhaus, D.E

Cell Metab (2007) 5:41525

Mohajeri, M., Horriatkhah, E

[140] developed transgenic coffee in which theobromine synthase (CaMXMT1) expression was reduced by RNAi utilizing CaMXMTI's 3 untranslated region (UTR)

That does not make it irrelevant but it does mean it should be discussed with a clinician who can weigh it against your specific inflammatory and hormonal profile, not pursued independently