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Selenium supplementation has been shown to reduce the size of thyroid nodules and goiter in specific Se-deficient individuals, but further studies are required to confirm these findings conclusively [76]

Realistically, you're looking at 3 months before you'd see early signs of response, and 6 months for a meaningful assessment

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After reading Khavinson et al

Clinical studies demonstrate that circulating lycopene increases with supplementation (pooled mean difference: 0.1361