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Crocin: A fighter against inflammation and pain

The sections were deparaffinized, hydrated, antigen retrieved, and then probed with primary antibodies against KIM-1, IL-1, TNF-, F4/80, 4-HNE, GPX4, Ferritin, and p53 at the dilution of 1:200, followed by the incubation with the secondary antibodies for 60min on the second day

The sequencing results came from the Changsha Qingke Biological Co., Ltd

Periportal hepatocytes (zone 1) have a substantial oxygen supply from arterioles responsible for gluconeogenesis, albumin synthesis, amino acid (AA) catabolism, cholesterol synthesis, and -oxidation, which need more ATP for energy supply

In addition, the oxidative damage induced by excessive ROS and decreases in antioxidants, such as superoxide dismutase and glutathione peroxidase in diabetes also causes mitochondrial dysfunction (63)