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Impact of patients satisfaction with their inhalers on treatment compliance and health status in COPD

2.2.2.2 Glutamine as a carbon donor One of the most important metabolic pathways involving glutamine is the biosynthesis of -KG to provide an anaplerotic supply for the TCA cycle

Collectively, these changes translate into a more pronounced improvement in mucosal barrier repair than that achieved with 5-ASA alone ( The combination of natural bioactive compounds with 5-ASA offers a novel therapeutic strategy for ulcerative colitis through a stage-specific, multi-target synergistic approach.These complementary mechanismsspanning acute immunomodulation, antioxidative damage, followed by active mucosal repair, and microbiota-metabolic regulationare visually integrated in Figure 2, which provides a comprehensive overview of their temporally coordinated actions

2 University of Colombo, Colombo 8, Sri Lanka

The analysis of mutational signatures in patients suggests that the selection of mutation-dependent oncogenic signals might trigger distinct phenotypes in permissive tissues 1,5,6