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Inhibition of death receptors or reduction of Fe 2+ significantly improved RGC survival, suggesting that concurrent regulation of multiple PCD pathways represents a critical strategy for treating retinal IR injury (139)

These findings aligned with our previous data which revealed that NAC-SNPs/pALG could markedly diminish oxidative stress, enhance blood circulation, and modulate the inflammatory response, thereby averting the significant hepatotoxicity and neoplastic alterations associated with BaP exposure

Probiotic genera include Lactobacillus, Streptococcus, and Bifidobacterium, which have widely varying effects in the body [188][189]

Given the heterogeneity of fibroblast populations, such ECM-driven reinforcement of fibrosis may disproportionately affect specific fibroblast subsets that are more prone to profibrotic activation, further emphasizing the importance of context-dependent therapeutic strategies that consider fibroblast diversity and their variable sensitivity to ferroptotic stress

According to the Expert consensus on TCM diagnosis and treatment of nonalcoholic fatty liver disease (2017) , NAFLD can be divided into five types: A