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Reviewer #1 The present manuscript describes the role of the GHSR in intracellular signaling on its own and in a variety of molecular interactions with other receptors as well as the potential for stimulation of GHSRs as a therapeutic target for a wide-range of clinical conditions

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Next, it will address how metabolic alterations related to senescence manifest in the clinical setting in exemplary diseases by affecting innate and adaptive responses, as well as tissue remodeling

The suture strings were transmitted in the conduit channel and pulled out in transverse directions and allowed the nerve stumps to insert into the conduit to a depth of about 3 mm (Fig