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The researchers thus hypothesized that blocking NNMT could open a novel path to treating obesity and its metabolic complications [1, 2]

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Moreover, inhibition of system xCT could lower the activity of GPX4, the vital antioxidant enzyme which allowed for blocking ferroptosis through reducing lipid hydroperoxides (Liu et al., 2017)

In Chronic Obstructive Pulmonary Disease (COPD), hypermethylation of the NRF2 promoter leads to decreased NRF2 expression in the lungs of patients, resulting in the inhibition of the NRF2-GPX4 axis and subsequent induction of ferroptosis