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AC was tested in maximal electroshock (MES), pentylenetetrazole (PTZ)-induced convulsions, and NMDA-induced mortality models in mice

10.3389/fnins.2019.00430 Front

Moreover, a range of bacteria, bacterial metabolites, and environmental toxins produced in the intestine can reach the liver through the portal vein [64], making the liver the most accessible place for intestinal bacteria and their derivatives