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Cognitive decline and gait disturbance are often observed simultaneously in SVD patients, also known as motoric cognitive dysfunction, but its shared underlying neural basis remains not fully understood

8-week-old SD rats, 3-week-old WKY rats and 3-week-old SHR rats were respectively purchased from Charles River Laboratories (Montreal, Quebec, Canada)

However, in the absence of matrix degradation, pore sizes smaller than 7 m 2 impede cellular locomotion because the nucleus, which is the stiffest and largest cell organelle, acts as a rate-limiting barrier to migration [170,171,172]

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