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Evidence from other neurodegenerative diseases suggests that the accumulation of mtDNA mutations itself may act as a trigger of microglial activation (95), supporting the possibility that metabolic changes in glia may alter glial inflammatory responses

Such a problem was noted in the EPIC study at the Norfolk, UK site

(2) the increasing BH4 content can remodel the lipid membrane environment by increasing the abundance of reduced CoQ10 and depleting the PUFA-PLs [52, 53]

doi: 10.3389/fvets.2025.1512701, 4 ChenY.OuZ.PangM.TaoZ.ZhengX.HuangZ.et al

"Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945-1965" (PDF)