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In RA patients, HK2 is highly expressed in the synovium, and it inhibits apoptosis and promotes FLS proliferation by acting on mitochondrial channel VDAC (82, 83, 88)

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Baccatin VI possesses significant antinociceptive activity against p- Benzoquinone -induced abdominal contractions

Autophagy-dependent cell death is considered as a regulated form of cell death that relies on the autophagic apparatus and generally adheres to the following criteria (1): elevated autophagy flux occurring simultaneously with cell death (2), reversibility of cell death when autophagy is inhibited through pharmacological or genetic means (3), dependence on at least two components of the autophagic process, and ( The notion of autophagy-dependent ferroptosis emerged amidst deepening investigations into ferroptosis, a form of cell death described in 2012 as iron-dependent and distinct from apoptosis, autophagy, and necrosis (49)

JB was partially supported by The Bloomberg Family Foundation