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LXRs also activate the transcription of inducible degrader of LDLR (IDOL), and E3 ligase that targets LDLR for ubiquitination and lysosomal degradation, to attenuate LDL uptake by cells (5, 6) ( Figure 1 )

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We based on our design and strategy from Julin Ceron Lab (IDIBELL Institute, Barcelona, Spain) (Vicencio et al , 2019)

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