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11,20,21 Additionally, non-pharmacological approaches, including lifestyle modifications, are being explored to enhance patient outcomes and quality of life

However, gemcitabine alone, or in combination with HGF/c-MET inhibition, significantly reduced proliferation

(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field