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These genes harbor mutations that affect various biological pathways, including complement regulation, lipid metabolism, extracellular collagen matrix, angiogenesis, and all- trans -retinaldehyde metabolism, to name a few

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In the latter case, the glutamate-induced oxidative stress is caused by an inhibition of the glutamate-cystine antiporter and subsequent promotion of cystine efflux and/or blockade of cystine uptake, which then results in reduction of intracellular glutathione and accumulation of intracellular ROS, and ultimately, oxidative cytotoxicity 35,36,37,38

The case used was 7 mm thick, showing artwork through the front, and also through the spine and part of the back of the case