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GSH depletion triggers the lymphocytes apoptotic cascade leading to lymphopenia that affects for the most part T lymphocytes, and lymphopenia is directly associated with severe disease and high mortality rate in COVID-19 patients (Pallard et al., 2009

This drop becomes more noticeable in chronic conditions

It directly scavenges ROS and reactive nitrogen species (RNS), including superoxide anions, hydroxyl radicals, nitric oxide, and carbon radicals [29,84,87]

Nevertheless, since omega-3 fatty acids and their metabolites might modulate pivotal molecular pathways including metabolic routes for the three amino acids (cysteine, glycine, and glutamate) needed for GSH biosynthesis, this feature could represent a promising eld of knowledge to be explored

Using preclinical models of breast cancer, the team also found they could slow tumor growth by blocking the cancers ability to use glutathione