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[22] [23] However, these mechanisms are primarily established in animal models with limited confirmation in human studies

Pathophysiology of mucositis involves a variety of mechanisms that extend beyond the immediate damage to the epithelium caused by chemotherapy

European registry data highlight that there are likely various genetic causes of IGF-I deficiency which remain poorly characterized, with a confirmed GHR deletion or mutation accounting for only 13% of children receiving rhIGF-1 enrolled in the EU Increlex Growth Forum Database registry [14]

The emergence of KEAP1 as a genetic regulator in chemotherapy-treated tumors may benefit from further investigation owing to this genes established role in antioxidative damage control

Al-Ziaydi, The role of adipokines and ghrelin in interactions and clinical implications in childhood obesity