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10.1016/j.ccr.2013.08.001 12 BissellM

52 Class I variants have very severe enzyme deficiency (less than 10% to.20% of normal) and have chronic hemolytic anemia

Parkinsons disease Parkinsons disease (PD) is a long-term neurodegenerative disorder that affects the motor system, characterized primarily by the death of dopaminergic neurons in the substantia nigra and the presence of intracellular aggregates of misfolded -synucleine (Lewy bodies) in the surviving neurons 54,55

Nygrd O, Refsum H, Ueland PM, and Vollset SE (1998)

Despite its many advantages, its clinical application is limited because of the progressive development of drug resistance after chemotherapy (26)