chac1 glutathione degradation of enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway Mammalian proapoptotic factor ChaC1 and

Mammalian proapoptotic factor ChaC1 and its homologues function as glutamyl cyclotransferases acting specifically on glutathione EMBO Reports Springer Nature Link BACH1CHAC1Glutathione Axis Aggravates Myocardial IschemiaReperfusion Injury by Enhancing Ferroptosis and Oxidative Stress CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers PMC Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element* Journal of Biological Chemistry

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