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BCL-2 mRNA levels consistently anti-correlated with the AR activity The preceding qmIF and IMC studies of BCL-2 and AR protein expression at the single-cell levels in patient CRPC and xenograft models revealed a reciprocal relationship between the two, suggesting that AR may transcriptionally represses BCL-2

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The paper summarizes results from years of experiments in rat models, demonstrating the cytoprotective effects of the pentadecapeptide on gastric mucosa exposed to ethanol, hydrochloric acid, NSAIDs, and immobilization stress

CPP-CAND disrupts FOXO4-p53 foci and induces apoptosis through caspase-dependent pathways FOXO4 is progressively recruited to euchromatin foci following senescence induction and is retained in the nucleus of senescent cells through its interaction with p53, contributing to the maintenance of the senescent state 34