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Complete bed rest is counterproductive and increases complication risk

Isoforms expressed in human tissues share 65% amino acid sequence identity but display different functions due to their differential expression (Tsukaguchi et al., 1999)

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Furthermore, ROS and RNS are able to control the activity of enzymes by triggering several post-translational modifications, such as disulfide bond formation, thiol oxidation to sulfenic/sulfinic/sulfonic acid, glutathionylation, nitrosylation and carbonylation