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Cancer Med 8:22522267

Figure 1 In H&E staining, all the enlarged thyroid left lobes of Braf thyrV600E mice at 12 months and of Braf thyrV600E , Mieap KO/KO and Braf thyrV600E , Atg5 thyrV600E mice at 6 and 12 months comparably showed papillary growth of atypical follicular cells exhibiting hyperchromatic irregularshaped nuclei and intranuclear cytoplasmic inclusions and follicular and nestic growth of atypical follicular cells with severe nuclear atypia as we have previously detected in Braf thyrV600E mice ( Figure 1C and data not shown)

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Have done 3 doses of first month and have had no negative side effects

The synthesized system displayed a highly pH-responsive behavior with a half-life of 0.2, 0.4, and 0.9 h at pH 4, 5, and 6, respectively which displayed a very good stability at pH 7.4