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This type of injection, which goes directly into the piriformis muscle, is primarily a diagnostic injection but may temporarily relieve your pain, sometimes just for a few hours

classified as a compounded drug with active import alerts Human trial evidence / Zero completed Phase II or III RCTs in any condition as of 2025 Tumor-promotion signal / Rat models show accelerated solid-tumor growth at supraphysiologic doses Cardiovascular concern / Dual vasomotor activity reported: hypotension at low doses, hypertension at high doses in rodents Hormonal interference / Modulates dopamine and serotonin pathways

Direct hits to the area can worsen the pain

Well as we have been using tranexamic acid to treat these patients since the 1980s, several of them also suffered from melasma, and reported this happy side effect of a clearer complexion

doi: 10.1136/openhrt-2019-001011