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Moreover, in a meta-analysis that included five studies focusing on type 2 diabetic patients, the alanine-encoding allele was associated with a reduced risk of macroalbuminuria (CR 0.65, 95% CI 0.520.80) compared with the valine-encoding allele (Tian et al., 2011)

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Oxidative stress involved in the pathogenesis of COPD is not only the result of the increased burden of oxidants but also owing to a decrease in antioxidative potential [38]

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171 In insulin resistance, elevated leptin levels reflect central leptin resistance, disrupting energy homeostasis and promoting hyperglycemia