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Several biomarkers, such as GPX4 and p53, have been identified for their regulatory effect on ferroptosis, and some compounds targeting these molecules to induce ferroptosis have already been found [9, 10]

8 mM of reducing agent DTT (Sigma) was then added to the samples and incubated in a thermomixer at 30C for 30 minutes, followed by the addition of 20 mM iodoacetamide (Sigma) for protein carboxylation with incubation at 30C in the dark for 30 minutes

In the senescent state, FOXO4 accumulates in PML (promyelocytic leukemia) nuclear bodies where it binds and sequesters p53, preventing p53 from activating the mitochondrial apoptotic pathway

Int Immunopharmacol 146:113801

Inhibition of MCAD in GBM cells (either genetically or pharmacologically) leads to the accumulation of medium-chain FAs, lipid peroxidation, and mitochondrial damage, resulting in apoptosis [124].An interesting use of FAO by glioma cells is to evade anti-tumor responses induced by radiotherapy