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Gwaltney-Brant, Accidental Overdosage of Joint Supplements in Dogs, J

Furthermore, PPE is capable of modulating several critical molecular pathways, including mitogen-activated protein kinases, nuclear factor-kappa B (NF-B), cysteine-aspartic acid-specific proteases, and peroxisome proliferator-activated receptors, thus providing theoretical support for its use in the treatment of a variety of diseases (Ganeshkumar et al., 2013

Thus, to clarify the interaction among these various inherited and nutritional factors and their relative involvement in cardiovascular disease, complementary prospective trials and experimental studies in transgenic animals should be performed in the future