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These cells exhibit a distinct morphology, characterized by their large size and vacuolated appearance

First, it has been shown in various types of cancer such as breast, prostate, and lymphoma that iron metabolism can be reprogrammed either by the upregulation of several iron intake pathways or the downregulation of iron export and storage pathways (100, 101)

Effects of thymosin beta-4 and its synthetic analog TB-500 on muscle injury recovery in animal models

It also oxidizes thiol groups of proteins, forming disulfide bonds that alter Bcl-2 family protein conformation and function, disrupting the balance between pro-apoptotic and anti-apoptotic proteins [79]

Histologic assessment and prognostic factors of malignant pleural mesothelioma treated with extrapleural pneumonectomy