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The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update

BBB impairment, including reduced expression or weakening of tight junctions, is responsible for the disruption of BBB integrity in PD, leading to increased vascular permeability and the accumulation of LBs, proteins and other intermediates, such as oligomeric -syn in neuronal cells, the basal ganglia and activated astrocytes from the SNpc [172, 173]

The reason behind this is that they can enhance metabolic function, encourage fat export from the liver, and provide nutritional support

Acid reflux causes inflammation and irritation in the esophageal lining

The study highlights that oxidative stress is not merely a byproduct of these illnesses, but a core, shared mechanistic driver of the pathology