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The non-solvent second phase is free from solvents for the polymer and active agent

not FDA-approved as of June 2026

In eukaryotic cells, negatively charged phospholipids are segregated into the inner leaflet of the membrane with the headgroup pointing towards the intracellular space

Abbreviations 3-UTR: 3-Untranslated region AAV: Adeno-associated virus AKT: Protein kinase B AMI: Acute myocardial infarction Ang II: Angiotensin II ANP: Atrial natriuretic peptide AS: Ankylosing spondylitis ASK1: Apoptosis signal-regulating kinase 1 BASDAI: Bath Ankylosing Spondylitis Disease Activity Index BNP: Brain natriuretic peptide BUN: Blood urea nitrogen CD: Crohns disease CDAA: Choline-deficient L-amino acid-defined CHD: Coronary heart disease CIA: Collagen-induced arthritis CIDEA: Cell death-inducing DFFA-like effector A CIDEC: Cell death-inducing DFFA-like effector C cKO: Conditional knockout CYP4A: Cytochrome P450 4A dKO: Double knockout DSP: Dual-specificity phosphatase (used for family name) DSS: Dextran sulfate sodium DUSP: Dual-specificity phosphatase (used for subgroup name) EAE: Experimental autoimmune encephalomyelitis EMT: Epithelial-to-mesenchymal transition ERK: Extracellular regulated kinase FAK: Focal adhesion kinase G6Pase: Glucose 6-phosphatase GDM: Gestational diabetes mellitus GLP-1: Glucagon-like peptide-1 GWAS: Genome-wide association study H/R: Hypoxia/reoxygenation HDAC3: Histone deacetylase 3 HDL: High-density lipoprotein HFD: High-fat diet HFHC: High-fat-high-cholesterol HUVEC: Human umbilical vein endothelial cell I/R: Ischemia/reperfusion IBD: Inflammatory bowel disease ICAM-1: Intercellular adhesion molecule 1 IGF-1: Insulin-like growth factor 1 IRS-1: Insulin receptor substrate 1 JNK: C-Jun N-terminal kinase KEGG: Kyoto Encyclopedia of Genes and Genomes KIM: Kinase-interacting motif KO: Knockout LN: Lupus nephritis LPS: Lipopolysaccharide MAPK: Mitogen-activated protein kinase MAS: Multiple autoimmune syndrome MI: Myocardial infarction MKP: MAP kinase phosphatase MTM: Myotubularin NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis NRVM: Neonatal rat ventricular myocyte OPG: Osteoprotegerin PBMC: Peripheral blood mononuclear cell PGC-1: PPAR- coactivator 1 PI3K: Phosphoinositide-3-kinase PTP: Protein tyrosine phosphatase RA: Rheumatoid arthritis S1P: Sphingosine-1-phosphate scRNA-seq: Single-cell RNA sequencing SLE: Systemic lupus erythematosus SNP: Single nucleotide polymorphism SS: Sjgren's syndrome SSH: Slingshot T2D: Type 2 diabetes TAK1: TGF--activated kinase 1 UC: Ulcerative colitis VCAM-1: Vascular cell adhesion molecule 1 -MHC: -Myosin heavy chain References Jeong DG, Wei CH, Ku B, Jeon TJ, Chien PN, Kim JK, et al

Topical products primarily affect surface layers of the skin