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In endosomes, Fe 3+ is reduced to Fe 2+ , which is then released from the endosomes into the cytoplasm, while the excess iron is retained in ferritin

[link] Cummings BJ, Uchida N, Tamaki SJ, Salazar DL, Hooshmand M, Summers R, Gage FH, Anderson AJ., "Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice", PNAS (2005)

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In the present study, we found significant differences in GST protein levels between MCI and AD patients after 1 year of follow-up, suggesting that GST protein levels may change more rapidly in the later stages of the disease