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Results: Bid-/- Bim-/- Puma-/- Bcl-xL(-/-) Mcl-1(+/-) mice showed significantly lower levels of serum ALT and smaller number of TUNEL positive hepatocytes than Bid-/- Bim-/- Puma+/+ Bcl-xL(-/-) Mcl-1(+/-) mice

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In addition to the roles of lactate mentioned above, recent study has revealed that in myelofibrosis (MF), the abnormal accumulation of lactate can remodel the bone marrow microenvironment, driving the fibrotic progression of the disease by inducing an immunosuppressive state and promoting collagen deposition (Spampinato et al., 2025)