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Similarly, coatomer protein complex subunit zeta 1 (COPZ1) is overexpressed in GBM [32], and its inhibition induces ferroptosis via NCOA4-mediated ferritin degradation, leading to Fe accumulation and ROS production through the Fenton reaction

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using fluoride concentrations with translational relevance, because the lower one (10 mg/L) represents the levels found in artificially fluoridated water supplies, and the higher (50 mg/L) represents fluoride levels in endemic regions of fluorosis 18

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Fleischer, Impact of a nutritional supplement (Impryl) on male fertility: Study protocol of a multicentre, randomised, double-blind, placebo-controlled clinical trial (SUppleMent Male fERtility, SUMMER trial), BMJ Open, 2020, doi: 10.1136/bmjopen-2019-035069