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Lancet Neurol 22:418429

The diagram below summarizes the potential changes that it can undergo

Pathologically, the disease is hallmarked by the presence of round, eosinophilic, intracytoplasmic inclusions called Lewy bodies (LBs) and dystrophic neurites (Lewy neurites) within surviving neurons (Forno, 1981)

Insulin increases Na+/K+ ATPase pump activity by increasing translocation (or movement) of alpha2 and beta1 pump subunits from an intracellular storage site to the plasma membrane (Sweeney & Klip, 1998), and through an increase in the sensitivity of the Na+/K+ ATPase pump to intracellular Na+ (Clausen, 1986, 2003