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Analysis of the national multicenter study (1976 to 1985) N Engl J Med

Soluble proteins and insoluble matrix were separated by centrifugation at 10,000 g

Sechenov First Moscow Medical University, Ministry of Health of the Russian Federation and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards

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To assess enhanced analgesia, the first assessment at time "0" was preceded by the application of morphine or saline 30 min before (time "-30 min"), by the application of haloperidol or saline 20 min (time "-20 min"), and, lastly, by the application of gastric pentadecapeptide BPC 157 or naloxone or saline (5 ml/kg i.p.) 10 min (time "-10 min")