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At the same time, there are paradoxes: small dogs often produce more ROS yet still accumulate fewer pathologies, while wild canids of comparable size live longer than domestic breeds, suggesting that selective breeding has altered antioxidant capacity

Just trying to see what one would see

IGF-1 replacement therapy induced a restoration of the altered GH/IGF-1 axis by reducing circulating GH levels and recovering the somatostatinergic tone [292]

doi: 10.1016/j.bbrc.2018.07.100 113 WangRNGreenJWangZDengYQiaoMPeabodyMet al

Consequently, nanoformulations of antioxidant phytochemicals enhance these effects by overcoming the barriers of poor solubility, rapid metabolism, and limited bioavailability [266]