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To determine if these findings extend beyond HCC, we performed additional experiments in the breast cancer cell line MDA-MB-468 and the lung cancer cell line A549

It inhibited tyrosinase reversibly in a competitive manner with K i = 4.03 0.26 mM and the binding of morin to tyrosinase-induced rearrangement and conformational changes of the enzyme 254

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For LC/MS data error bars represent SEM

Abbreviations 8-OH-DG: 8-OH-deoxyguanosine ACC: Acetyl-CoA carboxylase AD: Alzheimers disease AKAP1: A kinase anchoring protein 1 AP-1: Activator protein-1 BA: Bile acids BCL-2: B-cell lymphoma-2 BNIP3: Bcl2/adenovirus E1B 19 kDa interacting protein 3 CAD: Coronary artery disease cAMP: Cyclic adenosine monophosphate CDCA: Chenodeoxycholic acid circRNA: Circular RNA CRMP: Controlled release mitochondrial plasmin CVD: Cardiovascular disease DCA: Deoxycholic acid DNL: De novo lipogenesis DRAK2: Death associated protein related apoptotic kinase 2 Drp1: Dynamin-related protein 1 EGR: Early growth response eNOS: Endothelial nitric oxide synthase ER: Endoplasmic reticulum FADH2: Flavin adenine dinucleotide FAs: Fatty acids FFA: Free fatty acids FGF: Fibroblast growth factor FIS1: Fission protein 1 GFP: Green fluorescent protein GLP-1: Glucagon-like peptide-1 GSH: Glutathione GSSG: Glutathione disulfide GST: Glutathione-S-transferase GTP: Guanosine triphosphate GWAS: Genome-wide association studies H2O2: Hydrogen peroxide HCC: Hepatocellular carcinoma HD: Huntingtons chorea HDL: High-density lipoprotein HFD: High-fat diet HNE: 4-Hydroxy-2-nonenal HO-1: Heme oxygenase-1 IL-18: Interleukin-18 IL-1: Interleukin-1 IMM: Inner mitochondrial membrane JNK: c-Jun amino-terminal kinase LCA: Lithocholic acid LIR: LC3 interaction region MAFLD: Metabolic dysfunction-associated fatty liver disease MAMs: Mitochondria-associated endoplasmic reticulum membranes MERS: Mitochondrial-endoplasmic reticulum contact MFF: Mitochondrial fission factor MFN1: Mitofusin 1 MFN2: Mitofusin 2 Mito-Q: Mito-quinone MitoVit-E: MitoVitamin E MQC: Mitochondrial quality control Mst1: Macrophage-stimulated 1 mtDNA: Mitochondrial DNA MT-ND6: Mitochondria-encoded NADH dehydrogenase 6 (MT-ND6) MTP: Mitochondrial trifunctional protein complex NADH: Nicotinamide adenine dinucleotide NAFL: Non-alcoholic fatty liver NAFLD: Non-alcoholic fatty liver disease NASH: Nonalcoholic steatohepatitis NFB/Orai1: Nuclear factor kappa-B/calcium release-activated calcium modulator 1 Nix: Nip3-like protein X NLRP3: NODlike receptors family pyrin domain containing 3 NO: Nitric oxide NRF2: Nuclear factor E2-related factor 2 OLETF: Otsuka Long-Evans Tokushima Fatty OMM: Outer mitochondrial membrane OPA1: Optic atrophy 1 OXPHOS: Oxidative phosphorylation PARL: Progerin-associated rhodopsin-like PD: Parkinsons disease PINK: PTEN-induced putative kinase 1 PKA: Protein kinase A PNPLA3: Patatin-like phospholipase domain-containing 3 PPAR-: Peroxisome proliferator-activated receptor gamma PS1: Presenilin-1 ROS: Reactive oxygen species S1R: Sigma-1 receptor S637: Serine 637 SCD: Stearoyl-CoA desaturase SIRT3: Recombinant Sirtuin 3 SREBP1c: Sterol regulatory element binding protein 1c T2D: Type 2 diabetes TC: Total cholesterol TG: Triglycerides TGS: Triglycerides TM6SF2: Transmembrane 6 superfamily member 2 TNF-: Tumor necrosis factor- TPP: Triphenylphosphine TUDCA: Tauroursodeoxycholic acid TZDs: Thiazolidinediones UDCA: Ursodeoxycholic acid VLDL: Very low density lipoproteins References Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, Gortmaker SL