From your PNT article: Our results suggest that the measurement of B12 levels early in Parkinsons may be beneficial
If you fall into any of the categories above, it doesnt necessarily mean you have a deficiency
Initial improvements in texture and glow appear within 2 to 4 weeks

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A randomized, placebo-controlled study in 52 subjects (mean age, 30 years) with relapsing-remitting multiple sclerosis found an increase in total antioxidant capacity in blood with lipoic acid supplementation (1,200 mg/day for 12 weeks) yet not in the activity of specific antioxidant enzymes (superoxide dismutase and glutathione peroxidase) (97)