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Progressive growth of infantile cutaneous hemangiomas is directly correlated with hyperplasia and angiogenesis of adjacent epidermis and inversely correlated with expression of the endogenous angiogenesis inhibitor, IFN-beta

A reduction in the levels of GSH, and consequently of antioxidant defenses, may increase the risk of damage to the host via transcription factor activation leading to up-regulation of proinflammatory cytokines, such as nuclear transcription factors and activator proteins, induced in turn by agents such as hydrogen peroxide, mitogens, bacteria, viruses, and UV and ionizing radiation

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Tarangelo et al, 2018