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Vitamin B12, also known as cobalamin, is an important water-soluble vitamin involved in red blood cell production, brain health, and DNA synthesis ( A deficiency in this key vitamin can cause serious symptoms, including fatigue, nerve damage, digestive issues, and neurological problems like depression and memory loss ( Therefore, many people turn to vitamin B12 supplements to help meet their needs and prevent a deficiency

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Figure 15: Photograph of Joshua Lederberg working in his laboratory at the University of Wisconsin, October 1958

145 Zhu et al 56 demonstrated that COX-1 acts on endothelial cells through the mPGES-1/PGE2 pathway to regulate post-MIR microvascular function and improve cardiac function after MIR

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