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These findings are consistent with previous reports regarding the regulatory effect of SIRT2 on ERK: SIRT2 overexpression regulated type II collagen expression by activating ERK signaling in rabbit articular chondrocytes (Eo et al., Our recent study reported that NAD + induced increases in intracellular ATP levels under basal conditions through its degradation into adenosine (Zhang et al., + increases the GSH synthesis of the cells under basal conditions by an adenosine-independent pathway: while both NAD + and adenosine can increase GSH synthesis, AGK2 can reverse only the NAD + treatment-produced changes of the glutathione metabolism

This age of misinformation presents a challenge for orthopaedic surgeons, who must balance evidence-based guidance with growing public interest

& Badet-Denisot, M

Williams ET, Glauser L, Tsika E, Jiang H, Islam S, Moore DJ

Cells contain almost 90% of the Cd in the blood