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DNA hypermethylation: a kind of epigenetic modification that plays a key role in silencing tumour suppressor genes DNA methylation is one of the epigenetic mechanisms that is closely associated with normal cell development and a number of key processes including imprinting, X-chromosome inactivation, repression of repetitive element transcription, chromatin organization, etc

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Further, cell membrane coatings can be employed to make NPs mimic the properties exhibited by the source cells, thereby directly replicating a variety of complex functions (Hu et al., 2015

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