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It explains why simply taking oral B12 tablets won't work

Research suggests it may inhibit NNMT (Nicotinamide N-Methyltransferase), an enzyme linked to metabolic rate and fat cell energy regulation

The following are the most consistently reported signs: Sudden, sharp tightening in a specific muscle group (back, neck, leg, shoulder, calf, hand, or forearm) Muscle twitching or visible rippling beneath the skin a phenomenon called fasciculationsespecially in the abdomen, thighs, or eyelids A hard, knotted area in the muscle that is tender to the touch (often called trigger points or muscle knots) Reduced range of motion after a spasm, coupled with muscle stiffness lasting hours or days Burning or aching pain radiating from the spasm site common in cervical spasms and lumbar back spasms Nocturnal cramping waking from sleep due to leg cramps at night, charley horses, or toe cramps Stomach twitching or quivering in the abdomen, particularly with dehydration or electrolyte imbalance Root Causes of Persistent Muscle Cramps & Spasms Understanding what causes chronic muscle spasms is the most important step toward effective treatment

What low vitamin B12 levels can mean A low result usually reflects one of two problems: you are not taking in enough B12, or your body cannot absorb what you eat

10.1016/j.neuron.2012.01.034 83