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3.1.1 Micro-anatomical changes Renal biopsy primarily identifies nephrosclerosis and nephron hypertrophy

These effects of Pycnogenol supplementation on blood pressure were investigated in a small RDP crossover study with eleven borderline hypertension patients ( supplementation with 200 mg a day for eight weeks significantly lowered blood systolic blood pressure from 140 to 133 mmHg compared to placebo, which was decreased only marginally

Furthermore, PPP activity is increased in response to oxidative stress 64 , ionizing radiation 65 or chemotherapies 66 , which elicit high ROS levels and provoke an adaptive response by augmenting the PPP

In patients without oxidative stress markers, excessive supplementation may impair immune functioning