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Oxidative stress can also activate caspase-3 in muscle cells and promote degradation of the complete actin-myosin complex and apoptosis of muscle nucleus cells, resulting in muscle atrophy and loss of muscle nucleus (Orozco-Levi, 2003)

Mitochondrial dysfunction may accelerate the progression of insulin resistance and subsequent organ dysfunction and has different interconnections with eNOS, iNOS, nNOS and mtNOS

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