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Extensive research has been conducted on the decrease in melatonin levels that occurs during both normal ageing and pathological ageing processes in the pineal gland, the brain, and numerous other tissues outside of the pineal gland, as well as in bodily fluids such as cerebrospinal fluid, plasma, saliva, and urine (Wu and Swaab 2005

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Also, defective CL synthesis, a lipid specie of ceramide metabolism, might alter mitochondrial cristae structure reported in AD and PDs diseases (Argueti-Ostrovsky et al., 2024)

The aim of this work was to develop a fast, sensitive and simple method for the simultaneous determination of Cys, Hcy, GSH and N-Hcy-Lys in plasma samples that reduces the number of steps, shortens the total time of sample preparation and limits the amount of single-use polypropylene laboratory materials