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In contrast, the presence of albumin was associated with an enrichment of particularly lipids and some specific amino acid metabolites extracellularly (cluster 3

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Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104